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breast cancer chemo

New test for low-risk patients may cut out the chemo

July 22, 2017/in News /by katharine

Chemotherapy: we know how effective it can be. But we also know what an ordeal it can be, too. Which is why a recent report published in the journal JAMA Oncology may have extremely positive implications for thousands of breast cancer patients.

According to the report, the University of California have developed a new test – called MammaPrint – for cancer survivors. It examines 70 gene variants in blood and saliva which are known to increase the risk of cancer returning. In other words, it can predict which women are at low risk for years after they have surgery to remove cancerous tumours, which could allow those women – which make up half of early stage breast cancer patients – to avoid the severe physical and emotional traumas which are brought on by breast cancer chemo.

How the MammaPrint test works

Simply put, the MammaPrint test is a test of the genomes – the set of DNA within call of an organism – that has the potential to assess the chances of a recurrence of cancer. A sample of a cancer tumour is analysed to examine how active certain genes are, how the activity levels of the genes are affecting the behaviour of the cancer, and discovering how likely it is to grow and spread. The next stage would involve the doctor factoring in your age, your general health, the size and grade of the cancer and whether cancer cells were found in nearby lymph nodes in order to work out a treatment plan.

The research conducted so far suggests the MammaPrint test may eventually be widely used to help make treatment decisions based on the cancer’s risk of coming back within 10 years after diagnosis.

The end of unnecessary chemo?

Obviously, being able to deduce if a woman has a high or low risk of early-stage breast cancer coming back might be an enormous boon to the decision-making process over whether chemotherapy or other treatments to reduce risk after surgery are needed. Although the common perception is that breast cancer is breast cancer, we know that certain breast cancers pose little or no systemic risk. But the problem is that it’s been very hard to pin down and identify low-risk and high-risk cancers, necessitating a better-safe-than-sorry ethos.

Although the trialling of MammaPrint is still in the early stages, the initial results are very encouraging for both the medical community and those of us who have gone through breast cancer. For the former, a test that can accurately identify a section of women who have very little risk of their cancer recurring means that expensive and intensive treatments such as chemo can be safely factored out. For the latter, the more knowledge available the better – allowing patient and doctor to work out a more personalised therapy programme without unnecessary treatments.

Although the MammaPrint technique is still in its infancy, with no indication as to when it’ll be used in the UK, the study results are extremely encouraging – although it’s worth bearing in mind that the technique can only be used to analyse early-stage breast cancers.

https://www.thamesbreastclinic.com/wp-content/uploads/2017/07/breast-cancer-chemo-1.jpg 500 750 katharine https://www.thamesbreastclinic.com/wp-content/uploads/2016/07/Thames-Breast-Clinic-logo-preferred-300x139.png katharine2017-07-22 13:43:272017-08-04 08:23:16New test for low-risk patients may cut out the chemo
exercise and breast cancer

Simple exercise can fend off breast cancer, claims study

July 10, 2017/in News /by katharine

We’re all aware of the benefits of exercise and a healthy diet – even we don’t partake in either. But studies presented at a cancer conference hammered home the point by demonstrating that there is a link between exercise and breast cancer and a healthy fitness regime can improve survival rates for cancer sufferers.

One of the studies, which monitored the habits of 1,000 colon cancer patients, discovered that those who exercised regularly, ate more fruits and vegetables and avoided refined grains and meats had a 42% lower chance of death after seven years.

Another study – of 300 breast cancer survivors, conducted by the Queensland University of Technology – concluded that those who exercised for three hours a week had far better rates of survival than those who were not partaking in an exercise programme, even if the ‘exercise’ was as low-level as a regular walk.

Walk away from increased risk

The 300 subjects, who were six weeks out of surgery, were randomly assigned to groups that received exercise counselling or to a control group. The women who found themselves in the exercise counselling group were encouraged into attaining a simple goal: indulging in exercise for 180 minutes per week, in whatever manner they liked. Unsurprisingly, most chose the simplest, cheapest and easiest option: to walk.

After a median follow-up of roughly eight years, researchers discovered that 5.3% of the women who had received exercise counselling had died, versus 11.5% of those who had not. Similarly, 12.1% of women in the group that received exercise counselling had a recurrence of cancer, versus 17.7% of those who did not. Clearly, as the researchers pointed out at the conference, an exercise programme after treatment “has clear potential to influence survival”.

The colon cancer study – although specialising in a different form of cancer – also points the way for increased survival rates amongst women who have dealt with breast cancer, as it aimed to test whether the American Cancer Society’s dietary and exercise guidelines – which recommend 150 minutes of moderate exercise per week, sticking to a diet rich in whole grains, fruits and vegetables, and maintaining a healthy body weight – had any bearing on survival rates.

The results revealed a surprisingly strong link between a healthy diet and exercise regime and lowered mortality. Even the colon cancer survivors who drank moderately while following other guidelines had a 42% lower chance of dying than those that did not.

Food for thought

While we need to make clear that the majority of research into the influence of diet on breast cancer has produced findings which are inconclusive and inconsistent, there’s a lot to be said for cutting processed foods and red meat out of your diet and mixing in things like dark, leafy vegetables, olive oil, and fish that are rich in omega-3 fatty acids. For a full breakdown of what’s good and what isn’t – as well as an examination of a food myth or two – the Cancer Research website has a comprehensive list of dietary dos and don’ts.

 

https://www.thamesbreastclinic.com/wp-content/uploads/2017/07/exercise-and-breast-cancer-1.jpg 500 750 katharine https://www.thamesbreastclinic.com/wp-content/uploads/2016/07/Thames-Breast-Clinic-logo-preferred-300x139.png katharine2017-07-10 13:34:452017-08-04 08:20:33Simple exercise can fend off breast cancer, claims study

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